Alterations in binding site density of dopamine transporter in the striatum, orbitofrontal cortex, and amygdala in early Parkinson's disease: Compartment analysis for β‐CFT binding with positron emission tomography
Identifieur interne : 001E11 ( Main/Exploration ); précédent : 001E10; suivant : 001E12Alterations in binding site density of dopamine transporter in the striatum, orbitofrontal cortex, and amygdala in early Parkinson's disease: Compartment analysis for β‐CFT binding with positron emission tomography
Auteurs : Yasuomi Ouchi [Japon] ; Etuji Yoshikawa [Japon] ; Hiroyuki Okada [Japon] ; Masami Futatsubashi [Japon] ; Yoshimoto Sekine [Japon] ; Masaomi Iyo [Japon] ; Masanobu Sakamoto [Japon]Source :
- Annals of Neurology [ 0364-5134 ] ; 1999-05.
Abstract
We investigated changes in the kinetics in the binding of the dopamine transporter probe 2‐β‐carbomethoxy‐3β‐(4‐[11C]fluorophenyl)tropane (β‐CFT) in living brain by compartmental analysis, using positron emission tomography in unmedicated patients with Parkinson's disease (PD) (Hoehn and Yahr stages I–II). With dynamic positron emission tomographic data from 90‐minute acquisitions and metabolite‐corrected arterial input functions, binding potentials (k3/k4) were calculated by using estimated rate constants (K1 − k4). In this analysis, the magnitude of the distribution volume (K1/k2) measured in the cerebellum, in which specific binding is negligible, was used as a constrained value for fitting in binding regions. Statistics showed that k3/k4 values in the striatum, the orbitofrontal cortex, and the amygdala were significantly lower in PD patients than in normal controls, whereas there were no differences in K1/k2 ratios and structural volumes between the groups. Correlation analysis showed that the putaminal and orbitofrontal binding levels were correlated positively with motor and mentation scores, respectively, of the Unified Parkinson's Disease Rating Scale. These results indicated that not only the striatal but also the orbitofrontal and amygdalar presynaptic dopaminergic functions were altered in early PD. The reductions in these mesocortical/mesolimbic functions might contribute to the mental and behavioral impairment observed in PD. Ann Neurol 1999;45:601–610
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DOI: 10.1002/1531-8249(199905)45:5<601::AID-ANA8>3.0.CO;2-0
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Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-05">1999-05</date><biblScope unit="volume">45</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="601">601</biblScope><biblScope unit="page" to="610">610</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">A90F82326E2F0A7A5B8D1923E3BDE69C42FF132B</idno><idno type="DOI">10.1002/1531-8249(199905)45:5<601::AID-ANA8>3.0.CO;2-0</idno><idno type="ArticleID">ANA8</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated changes in the kinetics in the binding of the dopamine transporter probe 2‐β‐carbomethoxy‐3β‐(4‐[11C]fluorophenyl)tropane (β‐CFT) in living brain by compartmental analysis, using positron emission tomography in unmedicated patients with Parkinson's disease (PD) (Hoehn and Yahr stages I–II). With dynamic positron emission tomographic data from 90‐minute acquisitions and metabolite‐corrected arterial input functions, binding potentials (k3/k4) were calculated by using estimated rate constants (K1 − k4). In this analysis, the magnitude of the distribution volume (K1/k2) measured in the cerebellum, in which specific binding is negligible, was used as a constrained value for fitting in binding regions. Statistics showed that k3/k4 values in the striatum, the orbitofrontal cortex, and the amygdala were significantly lower in PD patients than in normal controls, whereas there were no differences in K1/k2 ratios and structural volumes between the groups. Correlation analysis showed that the putaminal and orbitofrontal binding levels were correlated positively with motor and mentation scores, respectively, of the Unified Parkinson's Disease Rating Scale. These results indicated that not only the striatal but also the orbitofrontal and amygdalar presynaptic dopaminergic functions were altered in early PD. The reductions in these mesocortical/mesolimbic functions might contribute to the mental and behavioral impairment observed in PD. Ann Neurol 1999;45:601–610</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Ouchi, Yasuomi" sort="Ouchi, Yasuomi" uniqKey="Ouchi Y" first="Yasuomi" last="Ouchi">Yasuomi Ouchi</name></noRegion><name sortKey="Futatsubashi, Masami" sort="Futatsubashi, Masami" uniqKey="Futatsubashi M" first="Masami" last="Futatsubashi">Masami Futatsubashi</name><name sortKey="Iyo, Masaomi" sort="Iyo, Masaomi" uniqKey="Iyo M" first="Masaomi" last="Iyo">Masaomi Iyo</name><name sortKey="Okada, Hiroyuki" sort="Okada, Hiroyuki" uniqKey="Okada H" first="Hiroyuki" last="Okada">Hiroyuki Okada</name><name sortKey="Sakamoto, Masanobu" sort="Sakamoto, Masanobu" uniqKey="Sakamoto M" first="Masanobu" last="Sakamoto">Masanobu Sakamoto</name><name sortKey="Sekine, Yoshimoto" sort="Sekine, Yoshimoto" uniqKey="Sekine Y" first="Yoshimoto" last="Sekine">Yoshimoto Sekine</name><name sortKey="Yoshikawa, Etuji" sort="Yoshikawa, Etuji" uniqKey="Yoshikawa E" first="Etuji" last="Yoshikawa">Etuji Yoshikawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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